Nyaung U is generally considered safe for solo female travelers. The locals are friendly and crime rates are low. However, it's always important to exercise caution, especially while traveling at night or in remote areas. Use your common sense and follow the local customs and traditions. While harassment and serious safety incidents are rare, it's wise to avoid deserted places after dark. Make sure to always inform someone about your whereabouts, keep your belongings secured, and ensure you have a reliable communication system for emergencies.