Kyaukme is generally safe for solo female travelers, but like any other places, caution and vigilance are needed. The locals are friendly and supportive, however, communication can be a bit challenging as not many people speak English. It would be best to stay in well-populated areas and avoid traveling alone at night. Make sure to respect local customs and dress codes, particularly when visiting religious sites. It is also handy to keep the contact information of your embassy or consulate.