Punta Del Este is generally a safe destination for solo female travelers. It's a well-known tourist city with a lot of families and visitors, so it is regularly patrolled and monitored. However, like any place, it is important to be aware of your surroundings, especially when out at night. Use reputable transportation services, and avoid isolated areas if you're alone. Public and tourist areas are well taken care of, locals are friendly and it's a very laid back city. Always trust your instincts and take usual safety precautions.