Piriapolis is generally a safe destination for solo female travelers. The locals are friendly and helpful, and most areas are well-patrolled by police. Nevertheless, it's important to always be aware of your surroundings. There may be occasional petty crimes like pickpocketing, particularly in crowded places or at the beach. Still, violent crimes are rare. Ensure to take standard safety precautions like being vigilant about personal belongings and avoiding deserted areas at night.