Kasese is a moderately safe place for solo female travelers. Like any location, it presents both challenges and rewards. While the local community is often friendly and willing to help, it is recommended that certain precautions be taken. Avoid walking alone at night in isolated areas and always keep an eye on your belongings. Use trusted transportation methods, preferably booked through your hotel. Overall, being vigilant, respectful, and maintaining a low profile can provide a better travel experience.