Saint Louis generally has a reputation for being safe, especially in areas frequented by tourists. That being said, like any other city, it's always important to take precautions. Avoid handling money openly in public, beware of pickpockets in crowded places, and avoid traveling alone at night in isolated areas. Utilize trusted local guides who know the area well when possible, and always be sure to share your itinerary with someone back home. Use your common sense and stay alert to your surroundings at all times.