Ometepe is relatively safe for solo female travelers. Like any travel destination, common sense and vigilance are crucial. Theft can be a problem especially if you leave your belongings unattended. Violent crime is rare, but it's important to be cautious, particularly at night. The locals are generally friendly and willing to help. Stay aware of your surroundings, don't display wealth, and avoid isolated areas, especially at night, to ensure a safe trip.