Nusa Penida in Indonesia is generally safe for solo female travelers. The locals are friendly and, like in many tourist spots in Indonesia, are respectful towards travelers. However, one should always maintain usual travel vigilance. The streets are less crowded at night, so planning your day accordingly and limiting nighttime exploration might be a good idea. Exploring the island could be challenging due to tricky roads and hilly terrain, so make sure to take caution if you rent a scooter. It is also a remote area, so medical help is quite limited- it's essential to have travel insurance.