Ponce is generally considered safe for solo female travelers. Like any location, it's always important to exercise common sense. Remain aware of your surroundings, especially at night. Crimes, such as pickpocketing, can still occur, but violent crime is not common, especially against tourists. There are plenty of safe and well-populated areas to explore, and the locals are friendly and helpful. It's recommended to stay in tourist-populated areas and not to wander off too far alone.