Humacao generally offers a safe environment for solo female travelers. Most of its residents are hospitable and helpful. The city is quite secure with a low crime rate, but as in any travel destination, keeping an eye on your personal belongings and avoiding remote areas at night is advised. Make sure to stay in well-lit places and be cautious while enjoying night-time activities. Local authorities are cooperative and ready to help in case of any issues. It's also recommended to respect local customs and traditions for a trouble-free stay.