Prilep is generally secure for solo female travelers. Visitors usually find it safe, friendly, and welcoming. People are open and helpful to tourists. The city has lower crime rates compared to other major cities worldwide. However, like any other place, it's always advisable to use caution and common sense. Avoid walking alone in poorly lit areas at late hours, look after your belongings, avoid displaying high-value items in public, and be aware of your surroundings at all times. Seek local advice for specific areas to avoid.