El Calafate is a popular destination for solo female travelers. It's a relatively safe city with a welcoming ambiance that could easily make anyone feel at home. Still, it's essential to be aware of your surroundings, use reliable transportation means, and limit traveling alone at night. Most locals are friendly and willing to help, but knowing some basic Spanish would be a great advantage. Moreover, as a traveler, it's a must to invest in travel insurance for any unforeseen emergencies.