Guyana, particularly its capital Georgetown, is best explored with heightened vigilance. While it doesn't have a high prevalence of incidents specifically targeting solo female travelers, issues like petty crime, theft, and occasional mugging do occur. Make sure to always be aware of your belongings, especially in crowded places, and avoid isolated areas or walking around at night. Local people are generally friendly and helpful. It's advised to make local contacts or converse with hotel staff about the places you plan to visit.